|
KMID : 0854720080280030205
|
|
Korean Journal of Asthma, Allergy and Clinical Immunology
2008 Volume.28 No. 3 p.205 ~ p.213
|
|
|
Human Cytotoxic T Lymphocyte-associated Antigen 4-immunoglobulin Fusion Protein Inhibits Airway Inflammation and Hyperresponsiveness in a Murine Model of Asthma
|
|
Jang Seong-Ok
Kim Byoung-Ju
Yu Jin-Ho
Song Young-Wha
Kang Mi-Jin
Jung Hyun-Don
Lee So-Yeon
Hong Se-hoon
|
|
|
Abstract
|
|
|
Background: CD4+ T helper cells which differentiate intothe Th2 cells are crucial for the initiation and progression
of allergic asthma. Human Cytotoxic T Lymphocyteassociated Antigen 4-immunoglobulin (CTLA4-Ig) has been widely used in order to block T-cell costimulation in an array of experimental animal models of T-cell-mediated diseases.
Objective: To evaluate whether human CTLA4-Ig fusion protein inhibits airway inflammation in a murine model of
OVA-induced asthma.
Method:
Result:In mice which were treated with the human CTLA4-Ig fusion protein before and after sensitization with
OVA, airway hyperresponsiveness and eosinophil count of BAL were markedly decreased. In mice which were treated
with human CTLA4-Ig before sensitization with OVA, serum total IgE level were more significantly reduced than that of positive control mice. Peribronchial inflammatory cell infiltration was desreased by the treatment of human CTLA4-Ig before and after sensitization with OVA.
Conclusion: These results suggest that human CTLA4-Ig fusion protein may inhibit eosinophilic airway nflammation and airway hyperresponsivness in OVA-sensitized and airway challenged mice.
|
|
|
KEYWORD
|
|
|
CTLA4-Ig fusion protein, Asthma, Mouse, Allergic inflammation, Airway hyperresponsiveness
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|